Targeting complement-mediated immunoregulation for cancer immunotherapy
نویسندگان
چکیده
منابع مشابه
Complement function in mAb-mediated cancer immunotherapy.
Complement activation by mAbs can cause direct tumor cell lysis or enhance antibody-dependent cell-mediated cytotoxicity. However, tumor cells are protected from complement-mediated injury by membrane-bound complement regulatory proteins (mCRP) that are often expressed at elevated levels on tumor cells. Recent studies indicate that blocking or overwhelming the function of tumor cell mCRP might ...
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ژورنال
عنوان ژورنال: Seminars in Immunology
سال: 2018
ISSN: 1044-5323
DOI: 10.1016/j.smim.2018.02.003